The Isaacs are a bluegrass Southern gospel music group consisting of mother Lily Isaacs (b. September 20, 1947), daughters Becky (b. Aug. 2, 1975) and Sonya Isaacs (b. July 22, 1974) and son Ben Isaacs (b. July 25, 1972), along with John Bowman (husband of Becky Isaacs) as an instrumentalist and songwriter. Joe Isaacs, formerly a singer and banjo player in the group, has left since his 1998 divorce from Lily Isaacs. He now does solo work on a far more localized level.

Former Kingsmen Quartet bass player, lead singer and baritone Tim Surrett was a member of group from 1997 until 2002. Surrett was married to Sonya Isaacs during this time period. Thomas Wywrot was a member from 2008 to 2011. Sonya Isaacs' husband, Jimmy Yeary, took his place.

Currently, the Isaacs consists of Sonya Isaacs Yeary, Lily Isaacs , Becky Isaacs Bowman and Ben Isaacs. On August 10, 2021 they were invited to become members of the Grand Ole Opry.

The group's roots go back to 1971, when Joe and Lily Isaacs began a bluegrass band. Lily's parents are Polish Jewish Holocaust survivors. A few years after they were liberated from a concentration camp in Germany in 1945, her parents moved two year old Lily to New York City, where, in 1958, she got a recording contract with Columbia Records and started performing in night clubs. While performing with his Kentucky band at the Gerde's Folk City, Joe met Lily and they were married in 1970. After Joe's brother died in an automobile accident, Joe and Lily became Christians, and the group began to perform only bluegrass gospel music. The group was initially named the Calvary Mountain Boys and later became Sacred Bluegrass before settling on the family name, the Isaacs. The group performed primarily on weekends, part-time, until 1986. As their son and daughters became old enough, they joined the group.

In 1992, the Isaacs moved from Morrow, Ohio, and settled in LaFollette, Tennessee.